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Chemical Manufacturing and Synthesis Services Specifications

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Processing Capability




   Processes:       
   Your choices are...
 
      
 
   Acylation / Alkylation (e.g., Friedel-Crafts)
 
     Acylation synthesis produces deactivated monoacylates through an electrophilic, aromatic substitution reaction between arenes and acyl chlorides or anhydrides. In the Friedel-Crafts Alkylation processes, the electrophilic aromatic substitution is catalyzed by a Lewis-acid and produces alkylated products through the reaction of arenes with alkyl halides or alkenes. Alkyl groups can activate arene, resulting in polyalkylated products.  Typically, Friedel-Crafts reactions for alkylation or acylation of aromatic compounds are catalyzed by aluminum chloride or other Lewis acids.
 
   Atomization / Powder Production
 
     Companies produce powders through an atomization, spray drying, milling, precipitation, or other proprietary process.
 
   Blending / Mixing
 
     Companies mix or blend materials. Mixers or blenders are driven by a shaft, speed reducer or electric motor.
 
   Compounding
 
     Companies provide compounding of plastics, rubber, elastomers, cleaning agents, lubricants, greases, masterbatch colorants (pigments, dyes), additive masterbatches, organic chemicals, chemical additives, metal working fluids, oils, oil and fuel additives, fuel mixtures, and other materials. Compounding mixes or blends and/or reacts all of the ingredients required to produce a finished product. For example, a compounded plastic resin or elastomer compound typically consists of base polymer resin(s), chemical additives, and reinforcing or extending fillers.
 
   Conversion / Forming
 
     Companies compact, form, cut or otherwise convert materials into different shapes or forms.
 
   Crystallization
 
     Crystallization cools a liquid solution or evaporates a solvent in order to form solid, solute crystals. As they leave the crystallizer, the slurry crystals are often forced through a circulation evaporator and may subsequently be separated from the liquid in a filter or centrifuge.
 
   Distillation
 
     Distillation applies and removes heat in order to separate a liquid or vapor mixture of two or more substances into component fractions of a desired purity. Chemicals and conditions determine which distillation processes can be used. Examples include no-pressure distillation, vacuum distillation, steam distillation, molecular distillation, and thin film distillation.
 
   Drying / Freeze Drying
 
     Drying uses evaporation, sublimation, or freeze drying processes to remove liquids or moisture from bulk solids, powders, parts, continuous sheets or other liquids.
 
   Esterification
 
     Companies perform esterification processes. In the Fischer-Speier esterification method, esterification of acids occurs by refluxing with excess alcohol in the presence of hydrogen chloride or other acid catalysts.

 
 
   Evaporation
 
     Evaporation is thermal separation or thermal concentration process that removes liquid from a solution, suspension, or emulsion by boiling.
 
   Fermentation / Biotransformations
 
     Companies use fermentation, biological catalysts or enzymatic compounds, microrganisms, and other biological agents or biotransformations to process or synthesize products. Fermentation is used in the production of drugs, foodstuffs and beverages. Enzymes are very effective at breaking down certain proteins. Composting is a biotransformation process that uses bacteria to break down organic waste.
 
   Filtration / Extraction
 
     Companies perform extraction or filtration processes.  Molecular sieve filtration often uses a porous molecular structure that selectively adsorbs or rejects molecules based on differences in molecular size or shape.
 
   Formulation
 
     Companies provide formulation services or develop formulas for chemical, polymer or material intensive products. Formulas provide ingredients, amounts, and processing instructions.
 
   Halogenation (e.g., Fluorination / Chlorination)
 
     Halogenation is the reaction, chemical combination or exposure of water or other chemicals to fluorine, chlorine, bromine, iodine or other halogens.  Exposing water to chlorine can destroy biological contaminants.  Halogenation processes include fluorination, chlorination, bromination, electrolytic fluorination and iodination as well as related processes such as iodine recovery.
 
   Hydroformylation / Formylation
 
     Companies perform hydroformylation or formylation reactions such as Duff, Gattermann-Koch or Vilsmeier-Haack. In Duff reactions, the formylation of phenols or aromatic amines with hexamethylenetetramine uses an acidic catalyst. Gattermann-Koch reactions are catalyzed by using aluminum chloride at high pressure in order to achieve the formylation of benzene, alkylbenzenes or polycyclic aromatic hydrocarbons with carbon monoxide and hydrogen chloride. Formylation of the amino acids in proteins is a naturally occurring process. 
 
   Hydrogenation
 
     Companies hydrogenate chemical or raw materials.  Hydrogenation is the reaction of hydrogen with another chemical or raw material. For example, Sorbital is formed through the hydrogenation of corn syrup. Formylation of the amino acids in proteins is a naturally occurring process. Fischer Tropsch (gas to liquids) or linear alpha olefin hydroformylation processes are used in the production of synthetic oils fluids. In the Fischer Tropsch reaction or Synthol process, hydrocarbons, aliphatic alcohols, aldehydes, and ketones are synthesized by the catalytic hydrogenation of carbon monoxide using synthesis gas enriched from the passage of steam over heated coke. The Bergius reaction is used to synthesize petroleum-like hydrocarbons by the hydrogenation of coal at high temperatures and pressures (~ 450°C @ 300 atm) with or without catalysts.
 
   Organometallic / Grignard Reactions
 
     Companies provide processing or expertise in using organometallic or Grignard reactions.  Originally, Grignard reactions were the addition of organomagnesium compounds or Grignard reagents to carbonyl compounds to generate alcohols. The reaction scope now includes the addition of Grignard reagents to a wide variety of electrophilic substrates.
 
   Oxidation Reactions
 
     Companies process chemicals or materials with an oxidation reaction such as epoxidation.
 
   Polymerization
 
     Companies use condensation, addition, or other reactions to polymerize or copolymerize monomers or intermediates into longer chain molecules.
 
   Reduction Reactions
 
     Companies use a reduction reaction to process chemicals or materials.
 
   Refining / Purification
 
     Companies perform refining or purification services.
 
   Sterilization / Disinfection
 
     Supplier has the capability to sterilize or disinfect chemicals, materials, surfaces or environmental media (water, soil, etc.) to kill or destroy any microbial contamination (mold, bacteria, viruses, protozoa, etc.).
 
   Synthesis
 
     Companies perform reactions to synthesize chemicals or materials.
 
   UV / Photochemical
 
     Companies provide ultraviolet (UV) light or photochemical processing services. UV light exposure is used to degrade, breakdown, sterilize certain compounds or chemicals. UV light or radiation sources are used to initiate reactions or cure certain polymers and resins.
 
   Other
 
     Other unlisted processes or reactions.
 
   Search Logic:      All products with ANY of the selected attributes will be returned as matches. Leaving all boxes unchecked will not limit the search criteria for this question; products with all attribute options will be returned as matches.
   Clean in Place
 
     Company facilities use clean-in-place (CIP) equipment that can be cleaned without disassembly. Typically, a spray device is used for cleaning.
 
   Search Logic:      "Required" and "Must Not Have" criteria limit returned matches as specified. Products with optional attributes will be returned for either choice.
   Clean Room
 
     Company facilities locate sterilization and/or manufacturing equipment in a clean room in order to eliminate or minimize the contamination of processed materials, chemicals or products.
 
   Search Logic:      "Required" and "Must Not Have" criteria limit returned matches as specified. Products with optional attributes will be returned for either choice.
   Cryogenic Processing
 
     Companies process chemicals or materials at very low or cryogenic temperatures. 
 
   Search Logic:      "Required" and "Must Not Have" criteria limit returned matches as specified. Products with optional attributes will be returned for either choice.
   Vacuum Processing
 
     Companies provide vacuum processing of chemicals or materials.
 
   Search Logic:      "Required" and "Must Not Have" criteria limit returned matches as specified. Products with optional attributes will be returned for either choice.
Chemicals Processed




   Chemicals / Chemical Products:       
   Your choices are...
 
      
 
   Acetylenes
 
     Companies process or synthesize acetylenes.
 
   Alcohols
 
     Companies process or synthesize alcohols.
 
   Biochemicals / APIs
 
     Companies process, react, extract or synthesize biochemicals such as proteins, peptides, amino acids, amino acid analogs, DNA, RNA, steroids, carbohydrates, oligonucleotides, lipids, animal fats, vegetable oils, waxes, sterols, triglycerides, other biological or botanical derivatives, active pharmaceutical ingredients (APIs) or high potency actives (HPAs). 
 
   Catalysts / Initiators
 
     Companies process or synthesize catalysts or initiators.
 
   Chemical Agents / Additives
 
     Companies process or synthesize chemical agents or additives such as stabilizers, plasticizers, flame retardants, release agents, etc.
 
   Cleaners / Surface Active Agents
 
     Companies process or produce cleaning and surface active agents such as cleaners, detergents, surfactants, emulsifiers, flocculants, dispersing agents, settling agents, and soaps (saponification end products).
 
   Coolants / Refrigerants
 
     Fluid processing systems are used in coolants, refrigerants, and mineral oils. Mineral oils include base oil, bright stock, coal oil, crude oil residues, lubricating oils, paraffin oils, pitch (long & short residues), and tar containing products.
 
   Cosmetics / Soaps
 
     Fluid processing systems are to process cosmetics such as algae extracts, bee’s wax, brown moss extracts, flower extracts, lanolin alcohols, root extracts, wool fatty acids, wool alcohols, and volatile oils and scents.
 
   Filler / Extenders
 
     Companies synthesize or process fillers or extenders.
 
   Inorganic Chemicals
 
     Companies synthesize or process inorganic chemicals.
 
   Lubricants / Greases
 
     Companies synthesize or process lubricants or greases.
 
   Monomers and Intermediates
 
     Companies synthesize or process monomers and intermediates.
 
   Oils and Fuels
 
     Companies synthesize or process oils and fuels. Applications include oil refining, re-refining, recovery, and recycling.
 
   Organic Chemicals
 
     Companies synthesize or process organic chemicals such as alcohols, alfol esters, detergents, fertilizers, glycol ethers, herbicides, halogenated hydrocarbons, insecticides, organometallic compounds, silicone oils, tall oils, turpentine, and waxes.
 
   Pharmaceuticals / Drugs
 
     Companies synthesize or process pharmaceuticals or drugs, a category that includes vitamins, amino-acid esters, antibiotics, beta-carotene, ferments, glucose derivatives, hormones, antioxidants, and indoles.
 
   Pigments / Dyes
 
     Companies synthesize or process pigments, dyes or other colorants.
 
   Polymers
 
     Companies synthesize or process polymers.
 
   Reagents
 
     Companies synthesize or process reagents.
 
   Solvents
 
     Companies synthesize or process solvents.
 
   Specialty / Other
 
     Other unlisted products.
 
   Search Logic:      All products with ANY of the selected attributes will be returned as matches. Leaving all boxes unchecked will not limit the search criteria for this question; products with all attribute options will be returned as matches.
Processing Capacity




   Run / Batch Size:       
   Your choices are...
 
      
 
   Laboratory / Benchtop Scale
 
     Typically, laboratory or benchtop scale means that processing capacity does not exceed a few pounds or a few gallons. Actual quantities vary based on the type of material. For example, laboratory scale quantities may be expressed in milligrams for nanomaterials and specialized biochemical compounds. Usually, one person can easily and safely operate laboratory scale equipment. This category excludes facilities whose function is to produce commercial quantities.
 
   Pilot Scale
 
     Pilot scale is a small-scale production process that is larger than laboratory scale and used to develop a subsequent full-scale process. Typically, pilot scale quantities are in the range of several drums (e.g., 55-gallon drums) or hundreds of pounds or gallons; however, quantities vary with the density and type of processed material, chemical or product. Pilot scale facilities are better than laboratory scale facilities at simulating production processes and can be used for troubleshooting, improving and optimizing processes.
 
   Production Lots / Field Scale
 
     Companies have commercial, production, field or industrial scale processing facilities. Typically, the processing ranges are in thousands of gallons or pounds; however, quantities vary by material, chemical, or product.
 
   Other
 
     Other process scales.
 
   Search Logic:      All products with ANY of the selected attributes will be returned as matches. Leaving all boxes unchecked will not limit the search criteria for this question; products with all attribute options will be returned as matches.
   Capacity (Volume Basis):
 
     Enter the the volume to process or synthesize.
 
   Search Logic:      User may specify either, both, or neither of the "At Least" and "No More Than" values. Products returned as matches will meet all specified criteria.
   Capacity (Mass Basis):
 
     Enter the mass or weight capacity to process or synthesize.
 
   Search Logic:      User may specify either, both, or neither of the "At Least" and "No More Than" values. Products returned as matches will meet all specified criteria.
Certifications / Quality Requirements




   Certifications / Quality Requirements       
   Your choices are...
 
      
 
   AS 9100
 
     AS 9001 is a set of quality guidelines and requirements published by the Society of Automotive Engineers (SAE) in cooperation with major aerospace manufacturers. AS 9001 is based on ISO 9001 but maintains a particular focus on the aerospace industry.
 
   cGMP Compliant
 
     Companies comply with current good manufacturing practices (cGMP).
 
   DOT
 
     Supplier is permitted by the U.S. Department of Transportation to ship or transport specific class (solid, hazardous, medical, etc.) waste or scrap materials. 
 
   EPA
 
     Supplier is permitted by the EPA for specific recycling or reclamation activities or processes wasters in full compliance with standards, guidelines and methods set forth by the Environmental Protection Agency (EPA).
 
   FDA Registered
 
     Company laboratories are accredited or accepted by the U.S. Food and Drug Administration (FDA).
 
   ISO
 
     Companies comply with International Standards Organization (ISO) standards. Examples include ISO 7779, ISO 9000, ISO 9001, ISO 9002, ISO 13485, ISO 14000 and ISO 17025. ISO 7779 covers acoustics and the measurement of airborne noise emitted by information technology (IT) and telecommunications equipment. ISO 9000 establishes standards for quality management. ISO 9002, a certification that has been superseded by ISO 9001:2000, is dedicated to continuous improvement. ISO 13485 covers medical devices, quality management systems and requirements for regulatory purposes. ISO 14000 establishes standards for environmental management, a term that describes a company’s efforts to minimize its harmful effects on the environment and improve its environmental performance. ISO 17025 outlines general requirements for the competence of testing and calibration laboratories.
 
   ISO 9001:2000
 
     ISO 9001:2000 establishes requirements for company quality management systems. Standards range from manufacturing to services such as design, development, production, and installation.
 
   ISO 14001
 
     ISO 14000 provides an internationally recognized framework for environmental management, measurement, evaluation and auditing. It does not prescribe environmental performance targets, but instead provides organizations with tools for assessing and controlling the impact of activities, products or services on the environment. These standards are designed to be flexible enough to be used by any organization of any size and in any field. They address the following subjects: environmental management systems, environmental auditing, environmental labels and declarations, environmental performance evaluation, and life cycle assessment.
 
   QS 9000
 
     QS 9000 is a quality standard for suppliers of DaimlerChrysler Corporation, Ford Motor Company, and General Motors Corporation. QS 9000 is based on the 1994 edition of ISO 9001, but contains additional requirements that are particular to the automotive industry. Specifically, QS 9000 applies to suppliers of production materials, production and service parts, heat-treating, painting and plating, and other finishing services.
 
   MIL-SPEC Certified
 
     Companies comply with military specifications (MIL-SPEC).
 
   RIOS (ISRI)
 
     Supplier is registered or certified to the RIOS standard requirements. RIOS is the Recycling Industry Operating Standard established by ISRI, Institute of Scrap Recycling Industries. RIOS provides management systems guidelines specifically targeted to plants, facilities and suppliers in the recycling industry.  RIOS standard addresses the quality, environmental, health & safety issues in recycling operations.
 
   State Certification
 
     Supplier is certified to State standards or recognized by the State as a valid recycling facility for a specific class of waste or scrap.  A recycler can be certified in multiple States.
 
   Other
 
     Other unlisted, specialized, or proprietary certification or standard.
 
   Search Logic:      All products with ANY of the selected attributes will be returned as matches. Leaving all boxes unchecked will not limit the search criteria for this question; products with all attribute options will be returned as matches.
Regional Preference




           
   Your choices are...
 
      
 
   North America
 
     Companies are located in the United States, Canada or Mexico.
 
   United States Only
 
     Companies are located in the United States.
 
   Northeast US Only
 
     Companies are located in the Northeast United States, namely Connecticut, Maine, Massachusetts, New Hampshire, New Jersey, New York, Pennsylvania, Rhode Island and Vermont.
 
   Southern US Only
 
     Companies are located in the Southern United States, namely Alabama, Arkansas, Delaware, Florida, Georgia, Kentucky, Louisiana, Maryland, Mississippi, Missouri, North Carolina, Oklahoma, South Carolina, Tennessee, Texas, Virginia, Washington D.C., and West Virginia.
 
   Southwest US Only
 
     Companies are located in the Southwest United States, namely Arizona, California, Colorado, Nevada, New Mexico and Utah.
 
   Northwest US Only
 
     Companies are located in the Northwest United States, namely Idaho, Montana, Oregon, Washington and Wyoming.
 
   Midwest US Only
 
     Companies are located in the Midwest United States, namely Illinois, Indiana, Iowa, Kansas, Michigan, Minnesota, Nebraska, North Dakota, Ohio, South Dakota and Wisconsin.
 
   Canada Only
 
     Companies are located in Canada.
 
   South / Central America Only
 
     Companies have facilities in South American countries such as Argentina, Brazil, or Chile; or in Central American countries such as Costa Rica, Honduras, Panama, etc.
 
   Europe Only
 
     Companies are located in Europe, namely Germany, Ireland, Italy, United Kingdom, etc.
 
   South Asia Only
 
     Companies are located in South Asia, namely India, Pakistan, Nepal, etc.
 
   Near East Only
 
     Companies are located in the Near East, namely Egypt, Israel, Saudi Arabia, etc.
 
   East Asia / Pacific Only
 
     Companies are located in East Asia, namely China, Japan, Taiwan, etc.
 
   Other
 
     Other unlisted country or region.
 
   Search Logic:      Products with the selected attribute will be returned as matches. Leaving or selecting "No Preference" will not limit the search criteria for this question; products with all attribute options will be returned as matches.
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Related Keywords
Selective Catalytic Reduction, catalyst, catalytic oxidation, Distillation Column, Crystallization, isocyanate, vacuum drying, solid state fermentation, Vacuum Distillation, Ethylene Oxide, Solvent Extraction, sterilization, thermal oxidation, Essential Oil Distillation, Hydrazine, Distillation Equipment, Hydrogenation Reactor, Fractional Distillation, Spray Drying, Flash Distillation




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